Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | TAOK3 | Q9H2K8 | 4/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | UBLCP1 | Q8WVY7 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503561 | 0.90 | CA1 (0.43) | CA1CA2ACHETAOK3TAOK1 | |
| SCHEMBL9506542 | 0.86 | CA1 (0.41) | CA1CA2ACHEDRD2DRD4 | |
| SCHEMBL9503346 | 0.77 | CA1 (0.41) | CA1CA2ACHETAOK3TAOK1 | |
| SCHEMBL9503472 | 0.75 | MTNR1A (0.48) | CA1CA2ACHEDRD2DRD4 | |
| SCHEMBL9506505 | 0.72 | DRD2 (0.43) | FABP4DRD2DRD4DRD3LMNA | |
| SCHEMBL9504450 | 0.71 | DRD2 (0.54) | DRD2DRD4DRD3LMNA | |
| Hydrochloric Acid SCHEMBL9507124 | 0.70 | DRD2 (0.55) | DRD2DRD4DRD3LMNA | |
| SCHEMBL22694038 | 0.67 | DRD2 (0.62) | DRD2DRD4DRD3LMNA | |
| SCHEMBL8019711 | 0.64 | DRD2 (0.55) | DRD2DRD4DRD3 | |
| SCHEMBL8548581 | 0.64 | CA1 (0.47) | CA1CA2ACHETAOK3TAOK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |