Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005152 | 0.84 | APEX1 (0.55) | MAPTLMNAAPEX1SMN1; SMN2PDK1 | |
| SCHEMBL9731903 | 0.83 | MAPT (0.50) | MAPTLMNAAPEX1PDK1ALDH1A1 | |
| SCHEMBL23768982 | 0.83 | HPGD (0.63) | MAPTLMNAAPEX1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6515444 | 0.83 | APEX1 (0.51) | MAPTLMNAAPEX1PDK1ALDH1A1 | |
| SCHEMBL9503759 | 0.78 | PDK1 (0.70) | MAPTLMNASMN1; SMN2PDK1ALDH1A1 | |
| SCHEMBL8780956 | 0.78 | MAPT (0.48) | MAPTLMNAAPEX1SMN1; SMN2PDK1 | |
| SCHEMBL8973769 | 0.76 | TXNRD1 (0.66) | MAPTLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL18779397 | 0.76 | ALDH1A1 (0.73) | MAPTLMNASMN1; SMN2ALDH1A1PDE7A | |
| SCHEMBL2001946 | 0.76 | APEX1 (0.43) | MAPTLMNAAPEX1SMN1; SMN2PDK1 | |
| SCHEMBL11749054 | 0.76 | PDK1 (0.58) | MAPTPDK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543865-A1 | BENZAMIDE DERIVATIVES | RHONE-POULENC RORER LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003412-A2 | BENZAMIDE DERIVATIVES | RHONE-POULENC RORER LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |