Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503559 | 0.81 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1 | |
| SCHEMBL9507465 | 0.81 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1 | |
| SCHEMBL9504777 | 0.79 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1ALDH1A1LARS1CYP1A2 | |
| SCHEMBL9503588 | 0.73 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1LARS1 | |
| SCHEMBL9504779 | 0.70 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1CYP2C9CYP2C19POLB | |
| SCHEMBL9503601 | 0.68 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1LARS1 | |
| SCHEMBL10431544 | 0.68 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL9560059 | 0.66 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1 | |
| SCHEMBL9428546 | 0.65 | CYSLTR2 (0.51) | CYSLTR2CYSLTR1 | |
| SCHEMBL9428542 | 0.65 | CYSLTR2 (0.51) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375348-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| US-4954513-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0375348-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |