Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 11/20 | 0.59 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BID | P55957 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504777 | 0.90 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29090154 | 0.86 | CYSLTR2 (0.66) | CYSLTR2CYSLTR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9505649 | 0.77 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9561465 | 0.77 | CYSLTR2 (0.54) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL8925768 | 0.74 | CYSLTR2 (0.78) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL6437479 | 0.74 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL125952 | 0.74 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL29473536 | 0.74 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 | |
| SCHEMBL9301491 | 0.74 | CYSLTR2 (0.78) | CYSLTR2CYSLTR1LTB4RBIDBCL2L1 | |
| Pobilukast SCHEMBL9508139 | 0.73 | CYSLTR2 (0.98) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375348-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| US-4954513-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0375348-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |