Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.57 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.57 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504779 | 0.90 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL29090154 | 0.84 | CYSLTR2 (0.66) | CYSLTR2CYSLTR1CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL9503588 | 0.83 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1LARS1 | |
| SCHEMBL9503926 | 0.79 | CYSLTR2 (0.37) | CYSLTR2CYSLTR1LARS1CYP2C9CYP2C19 | |
| SCHEMBL10431544 | 0.78 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9503601 | 0.76 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1LARS1 | |
| SCHEMBL9561465 | 0.75 | CYSLTR2 (0.54) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL8925768 | 0.73 | CYSLTR2 (0.78) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL125952 | 0.73 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 | |
| Pobilukast SCHEMBL29473536 | 0.73 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375348-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | claimed |
| US-4954513-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-04 | — | — | US | claimed |
| EP-0375348-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | claimed |
| EP-0375348-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| US-4954513-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0375348-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |