Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.66 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | SI | P14410 | 1/20 | 0.66 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.66 |
| ▸ | CACNA1C | Q13936 | 10/20 | 0.52 |
| ▸ | CACNA1F | O60840 | 7/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 7/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272515 | 0.85 | MGAM (0.56) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL7272519 | 0.81 | CACNA1C (0.53) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL9505368 | 0.81 | GAA (0.44) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL11007622 | 0.80 | CACNA1C (0.58) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL11373038 | 0.78 | CYP2C9 (0.57) | GAACACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9518606 | 0.77 | GAA (0.64) | MGAMAMY1AGAASIMGAM2 | |
| Oxodipine SCHEMBL332244 | 0.76 | GAA (0.91) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL11368968 | 0.76 | CACNA1C (0.53) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7265346 | 0.76 | CYP1A2 (0.80) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL8680780 | 0.75 | ADORA3 (0.67) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458823-B1 | A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-10-13 | — | — | EP | disclosed |
| US-5245039-A | PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-09-14 | — | — | US | disclosed |
| WO-1990009376-A1 | A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1990-08-23 | — | — | WO | disclosed |
| EP-0383320-A1 | A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1990-08-22 | — | — | EP | disclosed |