Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705708 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1ALDH1A1TSHRTDP1 | |
| SCHEMBL8705714 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1ALDH1A1TSHRTDP1 | |
| SCHEMBL14598537 | 0.83 | HPN (0.57) | PTGS2PTGS1ALDH1A1TSHRTDP1 | |
| SCHEMBL21241540 | 0.78 | HPN (0.47) | PTGS2PTGS1ALDH1A1TSHRTDP1 | |
| SCHEMBL15344011 | 0.75 | ALOX15 (0.75) | ALDH1A1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL2947022 | 0.75 | PTGS2 (0.47) | PTGS2PTGS1ALDH1A1TSHRTDP1 | |
| SCHEMBL22360314 | 0.75 | CA1 (0.64) | PTGS2PTGS1ALDH1A1TSHRTDP1 | |
| SCHEMBL5857102 | 0.75 | ALDH1A1 (0.52) | PTGS2PTGS1ALDH1A1TSHRTDP1 | |
| SCHEMBL190927 | 0.74 | ALDH1A1 (0.39) | PTGS2PTGS1ALDH1A1TSHRTDP1 | |
| SCHEMBL3157771 | 0.73 | TDP1 (0.52) | PTGS2PTGS1ALDH1A1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293895-B1 | PHENOLIC THIOETHERS AS INHIBITORS OF 5-LIPOXYGENASE | G.D. Searle & Co. (US) | 1993-08-11 | — | — | EP | claimed |
| US-4835190-A | Phenolic thioethers as inhbitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1989-05-30 | — | — | US | claimed |
| EP-0293895-A1 | Phenolic thioethers as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1988-12-07 | — | — | EP | claimed |
| EP-0293895-B1 | PHENOLIC THIOETHERS AS INHIBITORS OF 5-LIPOXYGENASE | G.D. Searle & Co. (US) | 1993-08-11 | — | — | EP | disclosed |
| US-4847305-A | Phenolic thioethers as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1989-07-11 | — | — | US | disclosed |
| US-4835190-A | Phenolic thioethers as inhbitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1989-05-30 | — | — | US | disclosed |