Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.59 |
| ▸ | PGR | P06401 | 7/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.59 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.59 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | TNF | P01375 | 1/20 | 0.59 |
| ▸ | IL6 | P05231 | 1/20 | 0.59 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.59 |
| ▸ | GLUL | P15104 | 1/20 | 0.59 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.59 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24862085 | 1.00 | NR3C1 (0.59) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL18971855 | 1.00 | NR3C1 (0.59) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL19718628 | 1.00 | NR3C1 (0.59) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL9504455 | 1.00 | NR3C1 (0.59) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL19718634 | 0.91 | NR3C1 (0.54) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL8085488 | 0.89 | NR3C1 (0.55) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL8085489 | 0.89 | NR3C1 (0.55) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL9488529 | 0.88 | PGR (0.62) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL5448816 | 0.88 | PGR (0.62) | NR3C1PGRHIF1ACYP3A4HSD17B10 | |
| SCHEMBL30375284 | 0.88 | PGR (0.62) | NR3C1PGRHIF1ACYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475676-B1 | Pregnane derivatives condensed in the 16,17 position with an N-substituted isoxazolidine ring as anti-inflammatory agents | CHIESI FARM SPA (IT) | 2020-05-27 | — | — | EP | disclosed |
| US-10280193-B2 | Isoxazolidine derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-05-07 | — | — | US | disclosed |
| US-20180066010-A1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-03-08 | — | — | US | disclosed |
| US-20180066010-A1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-03-08 | — | — | US | disclosed |
| US-9845337-B2 | Isoxazolidine derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-12-19 | — | — | US | disclosed |
| US-9845337-B2 | Isoxazolidine derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-12-19 | — | — | US | disclosed |
| EP-2716648-B1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARM SPA (IT) | 2017-06-14 | — | — | EP | disclosed |
| EP-2993178-A1 | GLUCOCORTICOID CONDENSED IN POSITION 16,17 WITH AN ISOXAZOLIDINE GROUP | CHIESI FARMACEUTICI S.p.A. (IT) | 2016-03-09 | — | — | EP | disclosed |
| US-20150057257-A1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-02-26 | — | — | US | disclosed |
| US-20150057257-A1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-02-26 | — | — | US | disclosed |
| US-8637662-B2 | Isoxazolidine derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-01-28 | — | — | US | disclosed |
| US-8637662-B2 | Isoxazolidine derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-01-28 | — | — | US | disclosed |
| US-20120234316-A1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-09-20 | — | — | US | disclosed |
| US-20110065678-A1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-03-17 | — | — | US | disclosed |
| US-20110065678-A1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-03-17 | — | — | US | disclosed |
| EP-0256095-B1 | ANTI-INFLAMMATORY CARBOXY PREGNANE DERIVATIVES | FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (US) | 1993-05-19 | — | — | EP | disclosed |
| US-4762919-A | STEROIDS | FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (US) | 1988-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057257-A1 | ISOXAZOLIDINE DERIVATIVES | IL5, TSLP, SERPINA6 | NR3C1 19/4885PGR 2154/4885HIF1A 646/4885 |
| US-20120234316-A1 | ISOXAZOLIDINE DERIVATIVES | IL5, TSLP, SERPINA6 | NR3C1 19/4885PGR 2154/4885HIF1A 646/4885 |
| US-20110065678-A1 | ISOXAZOLIDINE DERIVATIVES | NR3C2, NR3C1, MC2R | NR3C1 2/4885PGR 1856/4885HIF1A 2445/4885 |
| US-20180066010-A1 | ISOXAZOLIDINE DERIVATIVES | IL5, TSLP, SERPINA6 | NR3C1 19/4885PGR 2154/4885HIF1A 646/4885 |
| US-10280193-B2 | Isoxazolidine derivatives | IL5, TSLP, SERPINA6 | NR3C1 19/4885PGR 2154/4885HIF1A 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.