SCHEMBL950451

SCHEMBL950451

O=Cc1ccn(-c2ncccc2Cl)n1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
HSD11B1 P28845 1/20 0.35
ADORA2A P29274 1/20 0.34
TRPA1 O75762 2/20 0.33
MALT1 Q9UDY8 1/20 0.33
KCNH2 Q12809 1/20 0.33
TRPM8 Q7Z2W7 1/20 0.33
TRPV1 Q8NER1 1/20 0.33
NFE2L2 Q16236 2/20 0.33
MTOR P42345 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528589 0.84 ADORA2A (0.34) ALDH1A1HSD11B1ADORA2ATRPA1MALT1
SCHEMBL12529043 0.79 ADORA2A (0.33) ADORA2ATRPA1
SCHEMBL639253 0.78 HSD11B1 (0.35) HSD11B1ADORA2ATRPA1MALT1KCNH2
SCHEMBL28229875 0.78 TRPA1 (0.34) HSD11B1TRPA1MALT1KCNH2TRPM8
SCHEMBL951177 0.77 ADORA2A (0.33) HSD11B1ADORA2ATRPA1
SCHEMBL951178 0.77 ADORA2A (0.33) HSD11B1ADORA2ATRPA1
SCHEMBL950522 0.76 RPS6KA5 (0.34) HSD11B1ADORA2ATRPA1MALT1KCNH2
SCHEMBL27793748 0.76 RPS6KA5 (0.35) HSD11B1ADORA2ATRPA1MALT1KCNH2
SCHEMBL435321 0.76 RPS6KA5 (0.35) HSD11B1ADORA2ATRPA1MALT1KCNH2
SCHEMBL29859811 0.76 KDM4E (0.39) ALDH1A1HSD11B1ADORA2ATRPA1MALT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101287721-B Hydrazide compound and pesticidal use of the same SUMITOMO CO LTD 2013-03-27 CN disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
WO-2006000336-A9 ANTHRANILAMIDES SERVING AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2007-02-01 WO disclosed
WO-2006000336-A9 ANTHRANILAMIDES SERVING AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2007-02-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 ALDH1A1 238/4885HSD11B1 1797/4885ADORA2A 1216/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT ALDH1A1 436/4885HSD11B1 651/4885ADORA2A 3986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.