Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504518 | 0.88 | SIGMAR1 (0.64) | HRH1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9787492 | 0.87 | SIGMAR1 (0.62) | HRH1SIGMAR1 | |
| SCHEMBL9505914 | 0.87 | HRH1 (0.76) | HRH1 | |
| SCHEMBL9201118 | 0.86 | HTR1A (0.63) | HTR1ASLC6A4SIGMAR1HRH3 | |
| SCHEMBL17023775 | 0.85 | HRH1 (0.68) | HRH1HTR1ASLC6A4 | |
| SCHEMBL17297879 | 0.83 | SIGMAR1 (0.72) | HTR1ASLC6A4SIGMAR1HRH3 | |
| SCHEMBL8316153 | 0.82 | CYP2J2 (0.60) | HRH1 | |
| SCHEMBL17297948 | 0.79 | SIGMAR1 (0.78) | HTR1ASLC6A4SIGMAR1HRH3 | |
| SCHEMBL17031600 | 0.78 | HRH1 (1.00) | HRH1 | |
| SCHEMBL1333820 | 0.78 | HTR1A (0.71) | HTR1ASLC6A4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399547-B1 | USE OF 4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDYL-PHENYLALKANE DERIVATIVES FOR THE MANUFACTURE OF AN ANTIHISTAMINIC | SCHAPER & BRÜMMER GMBH & CO. KG (DE) | 1993-08-11 | — | — | EP | disclosed |
| US-5077301-A | 4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDYLPHENYLALKANE DERIVATIVES AS ANTIHISTAMINES AND METHODS OF TREATMENT OF AN ALLERGIC RESPONSE | SCHAPER & BRUEMMER GMBH & CO. KG (DE) | 1991-12-31 | — | — | US | disclosed |