Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.63 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | NPY2R | P49146 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9787492 | 0.99 | SIGMAR1 (0.62) | SIGMAR1CHRM2CHRM1CHRM3HRH1 | |
| SCHEMBL9504605 | 0.88 | HRH1 (0.64) | SIGMAR1HRH1 | |
| SCHEMBL9873080 | 0.86 | HRH1 (0.67) | SIGMAR1CHRM2CHRM3HRH1KCNH2 | |
| SCHEMBL6362147 | 0.83 | KCNH2 (0.83) | CHRM3HRH1KCNH2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9787478 | 0.83 | HRH1 (0.73) | CHRM2CHRM1CHRM3HRH1KCNH2 | |
| SCHEMBL17470860 | 0.82 | SIGMAR1 (0.65) | SIGMAR1CHRM2CHRM1CHRM3KDM4E | |
| SCHEMBL8316153 | 0.82 | CYP2J2 (0.60) | HRH1KCNH2NPY2RCYP2J2 | |
| Oxalic Acid SCHEMBL10461604 | 0.81 | HRH1 (0.60) | SIGMAR1CHRM2CHRM3HRH1KCNH2 | |
| SCHEMBL12013920 | 0.78 | SIGMAR1 (0.70) | SIGMAR1KDM4EALDH1A1MAPTACHE | |
| SCHEMBL28801570 | 0.78 | SIGMAR1 (0.70) | SIGMAR1CHRM2CHRM3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3115221-A | — | — | None | — | — | JP | disclosed |
| EP-0399547-B1 | USE OF 4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDYL-PHENYLALKANE DERIVATIVES FOR THE MANUFACTURE OF AN ANTIHISTAMINIC | SCHAPER & BRÜMMER GMBH & CO. KG (DE) | 1993-08-11 | — | — | EP | disclosed |
| US-5077301-A | 4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDYLPHENYLALKANE DERIVATIVES AS ANTIHISTAMINES AND METHODS OF TREATMENT OF AN ALLERGIC RESPONSE | SCHAPER & BRUEMMER GMBH & CO. KG (DE) | 1991-12-31 | — | — | US | disclosed |
| JP-H03115221-A | ANTIHISTAMINE AGENT | SCHAPER & BRUEMMER GMBH & CO KG | 1991-05-16 | — | — | JP | disclosed |
| EP-0399547-A2 | Use of 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkane derivatives for the manufacture of an antihistaminic | SCHAPER & BRÜMMER GMBH & CO. KG (DE) | 1990-11-28 | — | — | EP | disclosed |