Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 5/20 | 0.35 |
| ▸ | PPARD | Q03181 | 5/20 | 0.35 |
| ▸ | PPARA | Q07869 | 5/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | FABP4 | P15090 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405050 | 0.79 | TSHR (0.45) | TSHRLMNASLC22A6AKR1B1ALDH1A1 | |
| SCHEMBL15789267 | 0.77 | LMNA (0.43) | TSHRLMNASLC22A6ADRA1ANFKB1 | |
| SCHEMBL670146 | 0.77 | LMNA (0.43) | TSHRLMNASLC22A6ADRA1ANFKB1 | |
| SCHEMBL28284450 | 0.72 | ADRA1A (0.52) | TSHRLMNASLC22A6ADRA1ANFKB1 | |
| SCHEMBL114655 | 0.71 | TSHR (0.48) | TSHRLMNASLC22A6NFKB1PMP22 | |
| SCHEMBL27531416 | 0.71 | PRMT1 (0.48) | TSHRLMNASLC22A6ADRA1ANFKB1 | |
| SCHEMBL874912 | 0.69 | ALDH1A1 (0.52) | TSHRLMNASLC22A6NFKB1PMP22 | |
| SCHEMBL7286124 | 0.69 | TSHR (0.43) | TSHRLMNASLC22A6ADRA1ANFKB1 | |
| SCHEMBL39777 | 0.68 | ALDH1A1 (0.55) | TSHRLMNASLC22A6NFKB1PMP22 | |
| SCHEMBL22200111 | 0.67 | ADRA1A (0.46) | TSHRLMNAADRA1ANFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |