Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29090154 | 0.84 | CYSLTR2 (0.66) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL9504779 | 0.77 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL9504777 | 0.75 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL9301491 | 0.72 | CYSLTR2 (0.78) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL10459640 | 0.71 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1 | |
| SCHEMBL9561170 | 0.71 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1 | |
| SCHEMBL10475509 | 0.71 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1 | |
| SCHEMBL9561626 | 0.71 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1 | |
| SCHEMBL9561165 | 0.71 | CYSLTR2 (0.75) | CYSLTR2CYSLTR1 | |
| SCHEMBL9428546 | 0.71 | CYSLTR2 (0.51) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4937253-A | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-26 | — | — | US | claimed |
| EP-0365149-A2 | Leukotriene antagonist prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-25 | — | — | EP | claimed |
| US-5189226-A | Chemical intermediate for diacid | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-4937253-A | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-26 | — | — | US | disclosed |
| EP-0365149-A2 | Leukotriene antagonist prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |