Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10431544 | 0.90 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1KMT2AHPGDALDH1A1 | |
| SCHEMBL9560197 | 0.85 | CYSLTR2 (0.65) | CYSLTR2CYSLTR1KMT2AHPGDALDH1A1 | |
| SCHEMBL9505650 | 0.83 | CYSLTR2 (0.73) | CYSLTR2CYSLTR1 | |
| SCHEMBL9504779 | 0.77 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL29090154 | 0.74 | CYSLTR2 (0.66) | CYSLTR2CYSLTR1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL9503582 | 0.72 | CYSLTR2 (0.72) | CYSLTR2CYSLTR1HDAC1 | |
| SCHEMBL9503601 | 0.70 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1 | |
| SCHEMBL6449278 | 0.69 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1KMT2AHPGDALDH1A1 | |
| SCHEMBL9504777 | 0.69 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1KMT2AALDH1A1CYP2D6 | |
| SCHEMBL9505680 | 0.69 | CYSLTR2 (0.43) | CYSLTR2CYSLTR1KMT2ACYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375348-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| EP-0375348-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |