Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A11 | P48066 | 4/20 | 0.38 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.34 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10468445 | 0.83 | ALDH1A1 (0.32) | KMT2ACASP3SENP8SENP7SENP6 | |
| SCHEMBL9663763 | 0.70 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL8809346 | 0.69 | MMP9 (0.43) | KMT2ACASP3SENP8SENP7SENP6 | |
| SCHEMBL8807239 | 0.64 | MMP1 (0.43) | — | |
| SCHEMBL7172605 | 0.64 | MMP1 (0.43) | — | |
| SCHEMBL2923216 | 0.64 | MMP1 (0.43) | — | |
| SCHEMBL8807243 | 0.64 | MMP1 (0.43) | — | |
| SCHEMBL8888422 | 0.64 | MMP1 (0.43) | — | |
| SCHEMBL30861823 | 0.63 | SLC6A11 (0.53) | SLC6A11SLC6A1KMT2AMEN1TP53 | |
| SCHEMBL9384795 | 0.62 | ELANE (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321187-B1 | 6-(SUBSTITUTED METHYLENE)PENEMS | BEECHAM GROUP PLC (GB) | 1993-07-28 | — | — | EP | disclosed |
| US-4931434-A | Penem compounds | BEECHAM GROUP P.L.C. (GB) | 1990-06-05 | — | — | US | disclosed |
| EP-0321186-A1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | disclosed |
| EP-0321187-A1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | disclosed |