SCHEMBL9504909

SCHEMBL9504909

O=C(NC=CCc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O)C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
ALOX12 P18054 1/20 0.59
ADRA1A P35348 1/20 0.59
TK1 P04183 3/20 0.58
TK2 O00142 1/20 0.58
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
TSHR P16473 1/20 0.52
BLM P54132 1/20 0.52
PMP22 Q01453 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31074294 0.86 LMNA (0.42) LMNASMN1; SMN2ALOX12ADRA1ATK1
SCHEMBL13082855 0.84 LMNA (0.64) LMNASMN1; SMN2ALOX12ADRA1ATK1
SCHEMBL12060321 0.84 LMNA (0.64) LMNASMN1; SMN2ALOX12ADRA1ATK1
SCHEMBL22188739 0.83 LMNA (0.40) LMNASMN1; SMN2ALOX12ADRA1ATK1
SCHEMBL22188734 0.82 TYMS (0.43)
SCHEMBL2357026 0.81 TK1 (0.68) LMNASMN1; SMN2ALOX12ADRA1ATK1
SCHEMBL2357020 0.81 TK1 (0.68) LMNASMN1; SMN2ALOX12ADRA1ATK1
SCHEMBL1527279 0.81 TK1 (0.68) LMNASMN1; SMN2ALOX12ADRA1ATK1
SCHEMBL6737955 0.81 TK1 (0.64) LMNASMN1; SMN2ALOX12ADRA1ATK1
SCHEMBL13412992 0.81 TK1 (0.64) LMNASMN1; SMN2ALOX12ADRA1ATK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4642931-A1 METHODS OF SEQUENCING USING 3´ ALLYL BLOCKED NUCLEOTIDES Illumina, Inc. (US) 2025-11-05 EP disclosed
US-20250146066-A1 NUCLEOTIDES WITH A 3' AOM BLOCKING GROUP ILLUMINA CAMBRIDGE LIMITED (GB) 2025-05-08 US disclosed
WO-2024145154-A1 METHODS OF SEQUENCING USING 3´ ALLYL BLOCKED NUCLEOTIDES ILLUMINA, INC. (US) 2024-07-04 WO disclosed
EP-0210449-B1 PROLONGED CHEMILUMINESCENCE MILES INC. (US) 1993-07-28 EP disclosed
US-4950588-A DETECTION OF NUCLEIC ACID HYBRIDS, ANTIBODIES ANTIGENS MOLECULAR DIAGNOSTICS, INC. (US) 1990-08-21 US disclosed
EP-0198207-B1 SPECIFIC IODINATION OF NUCLEIC ACID MOLECULAR DIAGNOSTICS, INC. (US) 1989-12-20 EP disclosed
EP-0194545-B1 LABELLING OF OLIGONUCLEOTIDES MOLECULAR DIAGNOSTICS, INC. (US) 1989-12-06 EP disclosed
US-4853327-A THE PRECURSOR, AN OXIDIZING AGENT, PEROXIDASE, NITROGENEOUS COMPOUND AND ALKYLAMINE; DETECTION OF NUCLEIC ACID HYBRIDS AND PEROXIDASES; IMMUNOASSAY MOLECULAR DIAGNOSTICS, INC. (US) 1989-08-01 US disclosed
US-4818681-A Fast and specific immobilization of nucleic acids to solid supports MOLECULAR DIAGNOSTICS, INC. (US) 1989-04-04 US disclosed
US-4808520-A HYBRIDIZING WITH NUCLEIC ACID, THEN WITH NUCLEOSIDE TRIPHOSPHATE IN PRESENCE OF ENZYME MOLECULAR DIAGNOSTICS, INC. (US) 1989-02-28 US disclosed
US-4794073-A Detection of nucleic acid hybrids by prolonged chemiluminescence MOLECULAR DIAGNOSTICS, INC. (US) 1988-12-27 US disclosed
EP-0210449-A2 Prolonged chemiluminescence MILES INC. (US) 1987-02-04 EP disclosed
EP-0198207-A1 Specific iodination of nucleic acid MOLECULAR DIAGNOSTICS, INC. (US) 1986-10-22 EP disclosed
EP-0194545-A2 Labelling of oligonucleotides MOLECULAR DIAGNOSTICS, INC. (US) 1986-09-17 EP disclosed
EP-0192197-A2 Fast and specific immobilization of nucleic acids to solid supports MOLECULAR DIAGNOSTICS, INC. (US) 1986-08-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250146066-A1 NUCLEOTIDES WITH A 3' AOM BLOCKING GROUP NT5C3B, NSUN2, RNMT LMNA 1743/4885SMN1; SMN2 3692/4885ALOX12 2881/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.