Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9577997 | 0.85 | MAPT (0.33) | MAPTTSHRCYP2C19HPGDALOX12 | |
| SCHEMBL1726442 | 0.72 | — | — | |
| SCHEMBL10409103 | 0.72 | — | — | |
| SCHEMBL8428594 | 0.68 | MAPT (0.37) | MAPTESR1ESR2 | |
| SCHEMBL13835936 | 0.68 | ESR1 (0.37) | MAPTTSHRESR1ESR2 | |
| SCHEMBL11905978 | 0.66 | MAPT (0.36) | MAPTTSHRESR1ESR2 | |
| SCHEMBL2564446 | 0.65 | ESR1 (0.34) | MAPTESR1ESR2 | |
| SCHEMBL48955 | 0.65 | ESR1 (0.41) | MAPTTSHRESR1ESR2CYP2C19 | |
| SCHEMBL1719094 | 0.65 | GPR174 (0.37) | MAPTTSHRESR1ESR2HPGD | |
| SCHEMBL8844086 | 0.62 | AKT1 (0.53) | MAPTTSHRHPGDMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552306-A1 | NOVEL SILICONE-CONTAINING POLYMERS AND OXYGEN PERMEABLE HYDROPHILIC CONTACT LENSES THEREFROM | PERMEABLE TECHNOLOGIES, INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992007013-A1 | NOVEL SILICONE-CONTAINING POLYMERS AND OXYGEN PERMEABLE HYDROPHILIC CONTACT LENSES THEREFROM | PERMEABLE TECHNOLOGIES, INC. (US) | 1992-04-30 | — | — | WO | disclosed |
| WO-1992007014-A1 | NOVEL SILICONE-CONTAINING ACRYLIC STAR POLYMERS, BLOCK COPOLYMERS AND MACROMONOMERS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |