Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.52 |
| ▸ | RXRA | P19793 | 3/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GRN | P28799 | 2/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951285 | 0.89 | RXRA (0.49) | KLKB1RXRANR1H2NR1H3KDM4E | |
| SCHEMBL28773936 | 0.88 | RXRA (0.48) | KLKB1RXRANR1H2NR1H3ALDH1A1 | |
| SCHEMBL27775065 | 0.87 | KLKB1 (0.56) | KLKB1RXRANR1H2NR1H3KDM4E | |
| SCHEMBL3224886 | 0.85 | HTT (0.50) | KLKB1KDM4EGRNSORT1PTGS1 | |
| SCHEMBL2254831 | 0.84 | RXRA (0.48) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL27775081 | 0.82 | RXRA (0.57) | KLKB1RXRANR1H2NR1H3KDM4E | |
| SCHEMBL2257208 | 0.81 | PDE4B (0.56) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL2262183 | 0.81 | CARM1 (0.47) | KLKB1RXRANR1H2NR1H3TRPV1 | |
| SCHEMBL2257738 | 0.81 | RXRA (0.44) | KLKB1RXRANR1H2NR1H3KDM4E | |
| SCHEMBL950904 | 0.81 | GRN (0.72) | KLKB1KDM4EALDH1A1MAPTGRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622595-B2 | chemical intermediates to insecticides and anticoagulant inhibitors of factor Xa having a 1-halophenyl-3-trifluoromethylpyrazole moeity; 1-(1-chloro-2-phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-11-24 | — | — | US | claimed |
| US-20070244117-A1 | Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof | LEO PHARMA A/S (DK) | 2007-10-18 | — | — | US | claimed |
| EP-2121621-B1 | LXR AND FXR MODULATORS | EXELIXIS PATENT CO LLC (US) | 2014-05-07 | — | — | EP | disclosed |
| EP-2121621-B1 | LXR AND FXR MODULATORS | EXELIXIS PATENT CO LLC (US) | 2014-05-07 | — | — | EP | disclosed |
| CN-101287721-B | Hydrazide compound and pesticidal use of the same | SUMITOMO CO LTD | 2013-03-27 | — | — | CN | disclosed |
| CN-101679297-B | LXR and FXR modulators | EXELIXIS INC | 2012-01-11 | — | — | CN | disclosed |
| US-7998995-B2 | LXR and FXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998995-B2 | LXR and FXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998995-B2 | LXR and FXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7968573-B2 | Hydrazide compound and pesticidal use of the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-06-28 | — | — | US | disclosed |
| EP-1937664-B1 | HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME | SUMITOMO CHEMICAL CO (JP) | 2011-06-15 | — | — | EP | disclosed |
| CN-1543460-A | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | ��Ļ���Ű˾ | 2004-11-03 | — | — | CN | disclosed |
| US-20040214828-A1 | Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY | 2004-10-28 | — | — | US | disclosed |
| EP-1435785-A1 | IMINOBENZOXAZINES, IMINOBENZOTHIAZINES AND IMINOQUINAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-1417204-A1 | ORTHO-HETEROCYCLIC SUBSTITUTED ARYL AMIDES FOR CONTROLLING INVERTEBRATE PESTS | E. I. du Pont de Nemours and Company (US) | 2004-05-12 | — | — | EP | disclosed |
| US-20040063738-A1 | Substituted heterocyclic phthalic acid diamide arthropodicides | E.I. DU PONT DE NEMOURS AND COMPANY | 2004-04-01 | — | — | US | disclosed |
| EP-1341780-A2 | SUBSTITUTED HETEROCYCLIC PHTHALIC ACID DIAMIDE ARTHROPODICIDES | E. I. du Pont de Nemours and Company (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2003032731-A1 | IMINOBENZOXAZINES, IMINOBENZTHIAZINES AND IMINOQUINAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003016304-A1 | ORTHO-HETEROCYCLIC SUBSTITUTED ARYL AMIDES FOR CONTROLLING INVERTEBRATE PESTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |
| WO-2002048137-A2 | SUBSTITUTED HETEROCYCLIC PHTHALIC ACID DIAMIDE ARTHROPODICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214828-A1 | Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests | NR0B1, IPO5, RER1 | KLKB1 4627/4885RXRA 1529/4885NR1H2 748/4885 |
| US-20040063738-A1 | Substituted heterocyclic phthalic acid diamide arthropodicides | DDT, QDPR, DDX6 | KLKB1 3791/4885RXRA 1630/4885NR1H2 4270/4885 |
| US-20070244117-A1 | Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof | F9, F12, HDAC9 | KLKB1 2079/4885RXRA 79/4885NR1H2 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.