SCHEMBL9505990

SCHEMBL9505990

O=C(O)c1cc(=O)n(-c2cc(Cl)ccc2Cl)[nH]1

nearest known ligand 0.66

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALKBH5 Q6P6C2 13/20 0.66
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 2/20 0.49
MME P08473 1/20 0.46
NOTUM Q6P988 1/20 0.43
TP53 P04637 1/20 0.42
HTT P42858 1/20 0.42
MAPT P10636 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CTSA P10619 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10956122 0.88 ALKBH5 (0.66) ALKBH5ALDH1A1KDM4EMMENOTUM
SCHEMBL10949271 0.83 KDM4E (0.60) ALKBH5ALDH1A1KDM4ENOTUMMAPT
SCHEMBL10956802 0.83 ALKBH5 (0.58) ALKBH5ALDH1A1KDM4EMMEMAPT
SCHEMBL1266657 0.82 ALKBH5 (0.51) ALKBH5ALDH1A1KDM4EMAPTSMN1; SMN2
SCHEMBL11420507 0.80 ALDH1A1 (0.78) ALKBH5ALDH1A1KDM4EMMETP53
SCHEMBL9505312 0.80 ALKBH5 (1.00) ALKBH5ALDH1A1KDM4EMMEMAPT
SCHEMBL9505993 0.78 ALDH1A1 (0.41) ALKBH5ALDH1A1KDM4EMMENOTUM
SCHEMBL9507900 0.77 ALKBH5 (0.72) ALKBH5ALDH1A1KDM4EMMENOTUM
SCHEMBL11300860 0.77 ALKBH5 (0.72) ALKBH5ALDH1A1KDM4EMMEHTT
SCHEMBL10952398 0.77 ALKBH5 (0.58) ALKBH5ALDH1A1KDM4EMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0297397-B1 PREPARATION OF DIAZO AND AZO COMPOUNDS BAYER AG (DE) 1993-08-04 EP disclosed
US-4942225-A Preparation of diazo and azo compounds using azidoformamidium salts BAYER AKTIENGESELLSCHAFT (DE) 1990-07-17 US disclosed
EP-0297397-A2 Preparation of diazo and azo compounds BAYER AG (DE) 1989-01-04 EP disclosed
EP-0093306-B1 METHODS FOR THE PREPARATION OF AZO COMPOUNDS, AND AZO COMPOUNDS BAYER AG (DE) 1986-09-24 EP disclosed
US-4544738-A FIBER-REACTIVE YELLOW AND ORANGE DYES BASF AKTIENGESELLSCHAFT (DE) 1985-10-01 US disclosed
US-4511506-A Reactive bis-triazinyl stilbene dyes BASF AKTIENGESELLSCHAFT (DE) 1985-04-16 US disclosed
EP-0093306-A1 Methods for the preparation of azo compounds, and azo compounds BAYER AG (DE) 1983-11-09 EP disclosed
EP-0017768-B1 REACTIVE DYESTUFFS AND THEIR USE BASF Aktiengesellschaft (DE) 1981-11-25 EP disclosed
EP-0017768-A1 Reactive dyestuffs and their use BASF Aktiengesellschaft (DE) 1980-10-29 EP disclosed
US-3971741-A DISPERSION PIGMENTS BAYER AKTIENGESELLSCHAFT (DT) 1976-07-27 US disclosed