Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLL | Q9UGP5 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996379 | 0.89 | KDM4E (0.56) | POLLMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL30366428 | 0.82 | NQO1 (0.41) | ALDH1A1KDM4ETDP1RAB9ASMN1; SMN2 | |
| SCHEMBL1886099 | 0.82 | NQO1 (0.41) | ALDH1A1KDM4ETDP1RAB9ASMN1; SMN2 | |
| SCHEMBL13475464 | 0.78 | KDM4E (0.46) | POLLMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL1829004 | 0.78 | KDM4E (0.50) | POLLMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL7477968 | 0.78 | KDM4E (0.52) | POLLMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL11690019 | 0.77 | MAPT (0.59) | POLLMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL11727296 | 0.74 | L3MBTL1 (0.49) | MAPTALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL6901121 | 0.73 | MAPT (0.81) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9621313 | 0.73 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276436-B1 | PHOSPHINIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-16 | — | — | EP | disclosed |
| US-5006651-A | Rheumatic diseases, bone disorders | HOFFMAN-LA ROCHE INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4885283-A | Phosphinic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0276436-A1 | Phosphinic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-08-03 | — | — | EP | disclosed |