Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27974045 | 0.87 | CYP11B1 (0.43) | KDM4ECYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL9506392 | 0.86 | CYP11B1 (0.49) | KDM4ECYP11B1CYP11B2ALDH1A1HPGD | |
| SCHEMBL9507851 | 0.85 | KDM4E (0.45) | KDM4ECYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL9405472 | 0.85 | SQOR (0.51) | KDM4ECYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL9506551 | 0.84 | KDM4E (0.50) | KDM4ECYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL9506490 | 0.84 | CYP11B1 (0.45) | KDM4ECYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL9506414 | 0.82 | KDM4E (0.50) | KDM4ECYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL9507799 | 0.81 | KDM4E (0.52) | KDM4EMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL9507867 | 0.81 | KDM4E (0.52) | KDM4EMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL9506375 | 0.81 | KDM4E (0.52) | KDM4EMEN1KMT2ACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0317175-B1 | PYRIMIDINE DERIVATIVES | SEIKO EPSON CORPORATION (JP) | 1993-09-22 | — | — | EP | claimed |
| EP-0317175-A2 | Pyrimidine derivatives | SEIKO EPSON CORPORATION (JP) | 1989-05-24 | — | — | EP | claimed |
| EP-0317175-B1 | PYRIMIDINE DERIVATIVES | SEIKO EPSON CORPORATION (JP) | 1993-09-22 | — | — | EP | disclosed |
| EP-0317175-A2 | Pyrimidine derivatives | SEIKO EPSON CORPORATION (JP) | 1989-05-24 | — | — | EP | disclosed |