Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9511667 | 0.85 | TRPV4 (0.42) | CYP11B1CYP11B2KDM1AEGLN2TRPV4 | |
| SCHEMBL10532893 | 0.84 | NPC1 (0.53) | CYP11B1CYP11B2EGLN2NPSR1TRPV4 | |
| SCHEMBL9506146 | 0.84 | CYP2A6 (0.38) | CYP11B1CYP11B2EGLN2XDHTRPV4 | |
| SCHEMBL9506365 | 0.84 | KDM4E (0.48) | CYP11B1CYP11B2ARNPSR1ADORA2A | |
| SCHEMBL19935579 | 0.84 | PDE9A (0.40) | CYP11B1CYP11B2KDM1AEGLN2ADORA1 | |
| SCHEMBL12012492 | 0.84 | TRPV4 (0.47) | CYP11B1CYP11B2KDM1AEGLN2AR | |
| SCHEMBL17053356 | 0.83 | TRPV4 (0.38) | CYP11B1CYP11B2KDM1AEGLN2XDH | |
| SCHEMBL9506392 | 0.82 | CYP11B1 (0.49) | CYP11B1CYP11B2XDHHPGDKDM4E | |
| SCHEMBL9506512 | 0.82 | RAB9A (0.40) | CYP11B1CYP11B2EGLN2NPSR1XDH | |
| SCHEMBL15829138 | 0.82 | TRPV4 (0.37) | CYP11B1CYP11B2KDM1AEGLN2TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0317175-B1 | PYRIMIDINE DERIVATIVES | SEIKO EPSON CORPORATION (JP) | 1993-09-22 | — | — | EP | claimed |
| EP-0317175-A2 | Pyrimidine derivatives | SEIKO EPSON CORPORATION (JP) | 1989-05-24 | — | — | EP | claimed |
| EP-0317175-B1 | PYRIMIDINE DERIVATIVES | SEIKO EPSON CORPORATION (JP) | 1993-09-22 | — | — | EP | disclosed |
| EP-0317175-A2 | Pyrimidine derivatives | SEIKO EPSON CORPORATION (JP) | 1989-05-24 | — | — | EP | disclosed |