SCHEMBL14698109

SCHEMBL14698109

Cc1cc(Cl)cc2c(=O)oc(-c3cnn(CC(F)(F)F)c3-c3ncccc3Cl)nc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ METAP2 P50579 4/20 0.36
▸ CNR1 P21554 2/20 0.35
▸ F7 P08709 2/20 0.32
▸ F3 P13726 2/20 0.32
▸ F2 P00734 1/20 0.32
▸ F10 P00742 1/20 0.32
▸ C1R P00736 1/20 0.32
▸ CYP17A1 P05093 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32
▸ ELANE P08246 3/20 0.32
▸ ALDH1A1 P00352 1/20 0.31
▸ POLB P06746 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31
▸ APEX1 P27695 1/20 0.31
▸ KLK7 P49862 1/20 0.31
▸ KLK14 Q9P0G3 1/20 0.31
▸ KLK5 Q9Y337 1/20 0.31
▸ ABL1 P00519 1/20 0.31
▸ SMO Q99835 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14698532 0.86 METAP2 (0.32) METAP2CNR1KLK7KLK14KLK5
SCHEMBL14698533 0.86 METAP2 (0.32) METAP2CNR1KLK7KLK14KLK5
SCHEMBL14697319 0.77 F7 (0.37) F7F3F2F10C1R
SCHEMBL31377057 0.77 CYP17A1 (0.39) F7F3F2F10CYP17A1
SCHEMBL13072421 0.74 C1R (0.40) F7F3F2C1RELANE
SCHEMBL951337 0.74 F7 (0.48) F7F3C1RELANEALDH1A1
SCHEMBL950651 0.73 C1R (0.43) F7F3F2C1RELANE
SCHEMBL950123 0.72 CYP17A1 (0.37) F7F3F2F10C1R
SCHEMBL950620 0.71 CYP17A1 (0.39) F7F3C1RCYP17A1CYP1A2
SCHEMBL950813 0.71 GRIN1 (0.33) ELANEALDH1A1POLBMAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140243197-A1 CARBAMOYLMETHOXY- AND CARBAMOYLMETHYLTHIO- AND CARBAMOYLMETHYLAMINO BENZAMIDES FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2014-08-28 — — US disclosed
EP-2744785-A1 CARBAMOYLMETHOXY- AND CARBAMOYLMETHYLTHIO- AND CARBAMOYLMETHYLAMINO BENZAMIDES FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2014-06-25 — — EP disclosed
EP-2742027-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2014-06-18 — — EP disclosed
US-20140162875-A1 N-Thio-Anthranilamide Compounds and Their Use as Pesticides BASF SE (DE) 2014-06-12 — — US disclosed
WO-2013024171-A1 CARBAMOYLMETHOXY- AND CARBAMOYLMETHYLTHIO- AND CARBAMOYLMETHYLAMINO BENZAMIDES FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2013-02-21 — — WO disclosed
WO-2013024004-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2013-02-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140162875-A1 N-Thio-Anthranilamide Compounds and Their Use as Pesticides ANTXR2, NIT2, TXN METAP2 805/4885CNR1 1934/4885F7 3786/4885
US-20140243197-A1 CARBAMOYLMETHOXY- AND CARBAMOYLMETHYLTHIO- AND CARBAMOYLMETHYLAMINO BENZAMIDES FOR COMBATING INVERTEBRATE PESTS BCHE, GNMT, PTMS METAP2 944/4885CNR1 965/4885F7 3494/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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