Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27671408 | 0.82 | LMNA (0.43) | HDAC3HDAC1HDAC2HDAC6SMN1; SMN2 | |
| SCHEMBL5065804 | 0.79 | RIPK1 (0.53) | RIPK1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1529441 | 0.79 | RIPK1 (0.53) | RIPK1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5069200 | 0.79 | RIPK1 (0.53) | RIPK1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL11901745 | 0.76 | OPRD1 (0.36) | RIPK1SMN1; SMN2LMNA | |
| SCHEMBL26528332 | 0.75 | POLB (0.46) | HDAC3HDAC1HDAC2HDAC6SMN1; SMN2 | |
| SCHEMBL8648238 | 0.74 | AOC3 (0.49) | RIPK1SMN1; SMN2POLBKDM4EATM | |
| SCHEMBL12086360 | 0.73 | ALDH1A1 (0.53) | HDAC1HDAC6SMN1; SMN2LMNAPOLB | |
| SCHEMBL7395984 | 0.72 | RIPK1 (0.45) | RIPK1SMN1; SMN2LMNAPOLBKDM4E | |
| SCHEMBL11899881 | 0.72 | LMNA (0.40) | HDAC3HDAC1HDAC2HDAC6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| CN-1012500-B | Process for preparing aryl hydroxamates | SQUIBB & SONS INC (US) | 1991-05-01 | — | — | CN | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |