SCHEMBL9507663

SCHEMBL9507663

CN(C)c1ccc(C(CC(=O)c2ccc(Cl)c(Cl)c2)CC(=O)c2ccc(Cl)c(Cl)c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 4/20 0.51
SLC6A4 P31645 1/20 0.46
SLC6A3 Q01959 1/20 0.46
S1PR2 O95136 1/20 0.43
S1PR4 O95977 1/20 0.43
S1PR3 Q99500 1/20 0.43
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9503695 0.84 POLB (0.54) ALDH1A1GAAL3MBTL1
SCHEMBL9505825 0.80 ALDH1A1 (0.49) ALDH1A1GAAL3MBTL1
SCHEMBL9503986 0.78 KMT2A (0.56) ALDH1A1GAAL3MBTL1
SCHEMBL9505856 0.78 L3MBTL1 (0.63) ALDH1A1GAAL3MBTL1
SCHEMBL10586800 0.77 L3MBTL1 (0.45) ALDH1A1GAAL3MBTL1
SCHEMBL9503965 0.76 L3MBTL1 (0.69) ALDH1A1GAAL3MBTL1HDAC3HDAC4
SCHEMBL4109066 0.74 KMO (0.65) KMOSLC6A4SLC6A3HDAC3HDAC4
SCHEMBL30702485 0.71 TSHR (0.52) KMOSLC6A4SLC6A3ALDH1A1HDAC3
SCHEMBL19642672 0.71 KMO (0.75) KMOSLC6A4SLC6A3
SCHEMBL26923754 0.71 TSHR (0.52) KMOSLC6A4SLC6A3ALDH1A1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0395991-B1 3-AMINOPHENYL-1,5-PENTANEDIONES BASF Aktiengesellschaft (DE) 1993-06-23 EP disclosed
EP-0395991-A1 3-Aminophenyl-1,5-pentanediones BASF Aktiengesellschaft (DE) 1990-11-07 EP disclosed