Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510465 | 0.88 | GAA (0.38) | GAAL3MBTL1CYP19A1TAAR1KDM4E | |
| SCHEMBL27127079 | 0.80 | GAA (0.43) | GAAL3MBTL1CYP19A1TAAR1KDM4E | |
| SCHEMBL10432246 | 0.76 | L3MBTL1 (0.40) | GAAL3MBTL1CYP19A1TAAR1KDM4E | |
| SCHEMBL9671962 | 0.73 | NISCH (0.44) | HTR1AHTT | |
| SCHEMBL9507937 | 0.73 | CYP19A1 (0.43) | GAAL3MBTL1CYP19A1CYP2C19HTR1A | |
| SCHEMBL9507945 | 0.73 | CYP19A1 (0.43) | GAAL3MBTL1CYP19A1ALDH1A1CYP2C19 | |
| SCHEMBL8123944 | 0.73 | CYP19A1 (0.43) | GAAL3MBTL1CYP19A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL8131705 | 0.71 | HTR6 (0.47) | CYP19A1KDM4EALDH1A1HTR1A | |
| SCHEMBL9770197 | 0.68 | TDP1 (0.49) | CYP19A1ALDH1A1CYP3A4HTR1ASMN1; SMN2 | |
| SCHEMBL30400843 | 0.68 | BAD (0.49) | L3MBTL1KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564520-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-13 | — | — | EP | disclosed |
| WO-1992011011-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| EP-0492021-A1 | Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-01 | — | — | EP | disclosed |