Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385171 | 0.88 | SLC6A2 (0.41) | CYP19A1SLC6A2SLC6A4SLC6A3GAA | |
| SCHEMBL9507937 | 0.85 | CYP19A1 (0.43) | CYP19A1GAAL3MBTL1HTR1ANFKB1 | |
| SCHEMBL8123944 | 0.85 | CYP19A1 (0.43) | CYP19A1GAAL3MBTL1HTR1ANFKB1 | |
| Hydrochloric Acid SCHEMBL8131705 | 0.80 | HTR6 (0.47) | CYP19A1SLC6A4HTR1ANFKB1NFKB2 | |
| SCHEMBL9770197 | 0.79 | TDP1 (0.49) | CYP19A1HTR1AALDH1A1SMN1; SMN2 | |
| SCHEMBL4538637 | 0.77 | LTA4H (0.40) | SLC6A4HTR1AHTTCYP1A2 | |
| SCHEMBL3290570 | 0.75 | NFKB1 (0.48) | CYP19A1SLC6A2SLC6A4SLC6A3NFKB1 | |
| SCHEMBL4197898 | 0.73 | HTR1A (0.55) | SLC6A4HTR1AALDH1A1CYP2C19 | |
| SCHEMBL4907152 | 0.73 | HTR1A (0.55) | SLC6A4HTR1AALDH1A1CYP2C19 | |
| SCHEMBL8186813 | 0.73 | ADRA2A (0.60) | SLC6A2HTR1AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564520-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-13 | — | — | EP | disclosed |
| WO-1992011011-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| EP-0492021-A1 | Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-01 | — | — | EP | disclosed |