Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507940 | 0.88 | GAA (0.40) | GAAL3MBTL1TAAR1KDM4EMAPT | |
| SCHEMBL9671962 | 0.73 | NISCH (0.44) | HTR1A | |
| SCHEMBL9510461 | 0.73 | GAA (0.38) | GAAL3MBTL1KDM4ECYP19A1CYP2C19 | |
| SCHEMBL9385171 | 0.73 | SLC6A2 (0.41) | GAAL3MBTL1CYP19A1HTR1AHTR7 | |
| SCHEMBL9383431 | 0.72 | HTR6 (0.48) | KDM4EALDH1A1 | |
| SCHEMBL3073151 | 0.68 | ITGB2 (0.46) | GAAL3MBTL1KDM4EMAPTCYP19A1 | |
| SCHEMBL403982 | 0.68 | BAD (0.49) | L3MBTL1KDM4EMAPTCYP2C19CYP1A2 | |
| SCHEMBL30400843 | 0.68 | BAD (0.49) | L3MBTL1KDM4EMAPTCYP2C19CYP1A2 | |
| SCHEMBL10432246 | 0.67 | L3MBTL1 (0.40) | GAAL3MBTL1TAAR1KDM4EMAPT | |
| SCHEMBL8123944 | 0.64 | CYP19A1 (0.43) | GAAL3MBTL1KDM4EMAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564520-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-13 | — | — | EP | disclosed |
| WO-1992011011-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| EP-0492021-A1 | Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-01 | — | — | EP | disclosed |