Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALPL | P05186 | 2/20 | 0.49 |
| ▸ | ALPI | P09923 | 2/20 | 0.49 |
| ▸ | ALPG | P10696 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9692646 | 0.85 | NAMPT (0.38) | SMN1; SMN2MAPTKMT2AHTTALPL | |
| SCHEMBL636639 | 0.84 | GAA (0.50) | SMN1; SMN2MAPTHTTGAAAR | |
| SCHEMBL6483278 | 0.84 | MAPT (0.55) | SMN1; SMN2MAPTKMT2AHTTGAA | |
| SCHEMBL7016502 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTKMT2AHTTMAPK10 | |
| SCHEMBL6474729 | 0.79 | ATP4A (0.55) | SMN1; SMN2MAPTKMT2AGAATP53 | |
| SCHEMBL27990243 | 0.77 | KDM4E (0.47) | SMN1; SMN2MAPTKMT2AHTTGAA | |
| SCHEMBL9509195 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2MAPTKMT2AHTTGAA | |
| SCHEMBL31325599 | 0.77 | NPC1 (0.51) | SMN1; SMN2MAPTKMT2AHTTGAA | |
| SCHEMBL10867808 | 0.77 | GAA (0.43) | SMN1; SMN2MAPTKMT2AHTTGAA | |
| SCHEMBL9398067 | 0.77 | ATP4A (0.42) | SMN1; SMN2MAPTKMT2AHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204215-B1 | 2-[(1H-benzimidazol-2-ylsulfinyl)methyl]-benzenamines | G.D. Searle & Co. (US) | 1993-08-11 | — | — | EP | claimed |