SCHEMBL636639

SCHEMBL636639

[O-][S+](Cc1ccccc1)c1nc2ccccc2[nH]1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.50
RAB9A P51151 7/20 0.49
NPC1 O15118 6/20 0.49
SMN1; SMN2 Q16637 4/20 0.46
TP53 P04637 2/20 0.46
KDM4E B2RXH2 3/20 0.45
ALDH1A1 P00352 3/20 0.45
HSD17B10 Q99714 3/20 0.45
HTT P42858 2/20 0.45
AR P10275 2/20 0.45
HPGD P15428 1/20 0.45
ABCB11 O95342 1/20 0.43
PKM P14618 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
MAPT P10636 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
EGFR P00533 1/20 0.41
ERBB2 P04626 1/20 0.41
MAPK1 P28482 1/20 0.41
DDAH1 O94760 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31325599 0.88 NPC1 (0.51) GAARAB9ANPC1SMN1; SMN2TP53
SCHEMBL10867808 0.88 GAA (0.43) GAARAB9ANPC1SMN1; SMN2TP53
SCHEMBL6483278 0.84 MAPT (0.55) GAARAB9ANPC1SMN1; SMN2TP53
SCHEMBL9507972 0.84 SMN1; SMN2 (0.49) GAARAB9ANPC1SMN1; SMN2TP53
SCHEMBL9509188 0.84 RAB9A (0.54) GAARAB9ANPC1SMN1; SMN2TP53
SCHEMBL9692781 0.84 KDM4C (0.37) GAARAB9ANPC1SMN1; SMN2TP53
SCHEMBL7016502 0.81 SMN1; SMN2 (0.60) RAB9ANPC1SMN1; SMN2TP53KDM4E
SCHEMBL6480385 0.81 ALDH1A1 (0.40) GAARAB9ANPC1SMN1; SMN2TP53
SCHEMBL6475609 0.80 ATP4A (0.50) GAARAB9ANPC1SMN1; SMN2TP53
SCHEMBL7289169 0.80 RAB9A (0.46) GAARAB9ANPC1SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7785630-B2 Preparation and administration form comprising an acid-labile active compound NYCOMED GMBH (DE) 2010-08-31 US claimed
WO-2006086978-A2 USE OF DEUTERATED N-[2-(5-METHOXY-1H-INDOL-3-YL)-ETHYL]ACETAMIDES AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND MEDICAMENTS CONTAINING SAID COMPOUNDS BIRDS PHARMA GMBH BEROLINA INNOVATIVE RESEARCH & DEVELOPMENT SERVICES (DE) 2006-08-24 WO claimed
EP-4072532-B1 DOSAGE FORM FOR USE IN TREATING OR PREVENTING OF A DISEASE EVONIK OPERATIONS GMBH (DE) 2024-01-24 EP disclosed
US-11730708-B2 Dosage form for use in treating or preventing of a disease EVONIK OPERATIONS GMBH (DE) 2023-08-22 US disclosed
US-20230048354-A1 DOSAGE FORM FOR USE IN TREATING OR PREVENTING OF A DISEASE EVONIK OPERATIONS GMBH (DE) 2023-02-16 US disclosed
US-20230012981-A1 DOSAGE FORM FOR USE IN TREATING OR PREVENTING OF A DISEASE EVONIK OPERATIONS GMBH (DE) 2023-01-19 US disclosed
CN-114786652-A Dosage forms for treating or preventing diseases 赢创运营有限公司 2022-07-22 CN disclosed
WO-2021115650-A1 DOSAGE FORM FOR USE IN TREATING OR PREVENTING OF A DISEASE EVONIK OPERATIONS GMBH (DE) 2021-06-17 WO disclosed
EP-2112920-B1 PROTON PUMP-INHIBITOR-CONTAINING CAPSULES WHICH COMPRISE SUBUNITS DIFFERENTLY STRUCTURED FOR A DELAYED RELEASE OF THE ACTIVE INGREDIENT INTELLIPHARMACEUTICS CORP (CA) 2018-07-25 EP disclosed
US-9636306-B2 Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient INTELLIPHARMACEUTICS CORP. (CA) 2017-05-02 US disclosed
US-20160324723-A1 PHARMACEUTICAL PRODUCT FOR INJECTION TAKEDA GMBH (DE) 2016-11-10 US disclosed
US-6328993-B1 Oral administration form for an acid liable active proton pump inhibitor BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2001-12-11 US disclosed
US-20010047038-A1 Method of using (H+/K+) ATPase inhibitors as antiviral agents MOORMAN ALAN E (US) 2001-11-29 US disclosed
US-5945425-A ADENOSINE TRIPHOSPHASE INHIBITOR; DNA VIRICIDE G.D. SEARLE & CO. (US) 1999-08-31 US disclosed
WO-1995029897-A1 METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS G.D. SEARLE & CO. (US) 1995-11-09 WO disclosed
EP-0218336-B1 USE OF BENZYLSULFINYLBENZIMIDAZOLES AS CYTOPROTECTIVE AGENTS FOR THE GASTROINTESTINAL TRACT NIPPON CHEMIPHAR CO., LTD. (JP) 1991-12-18 EP disclosed
US-4772619-A ANTIULCER AGENTS G. D. SEARLE & CO. (US) 1988-09-20 US disclosed
US-4721718-A 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers G. D. SEARLE & CO. (US) 1988-01-26 US disclosed
US-4687775-A ANTIULCER AGENTS G. D. SEARLE & CO. (US) 1987-08-18 US disclosed
EP-0218336-A2 Use of benzylsulfinylbenzimidazoles as cytoprotective agents for the gastrointestinal tract NIPPON CHEMIPHAR CO., LTD. (JP) 1987-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010047038-A1 Method of using (H+/K+) ATPase inhibitors as antiviral agents ATP4A, ATP1A1, ATP1A4 GAA 160/4885RAB9A 486/4885NPC1 363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.