Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510377 | 0.90 | LTB4R (0.55) | PPARALTB4RLTB4R2KMT2A | |
| SCHEMBL9579690 | 0.88 | LMNA (0.47) | PPARALTB4RLTB4R2 | |
| SCHEMBL9510487 | 0.82 | BID (0.48) | PPARALTB4RLTB4R2 | |
| SCHEMBL9579709 | 0.80 | LTB4R (0.46) | PPARALTB4RLTB4R2 | |
| SCHEMBL3544218 | 0.78 | ALOX5 (0.58) | PPARAALOX5PTGS2 | |
| SCHEMBL3546860 | 0.78 | TPMT (0.58) | PPARAKMT2AALOX5PTGS2 | |
| SCHEMBL3547398 | 0.77 | ALOX5 (0.57) | PPARAALOX5PTGS2 | |
| SCHEMBL9506680 | 0.77 | CYSLTR2 (0.52) | PPARALTB4RLTB4R2KMT2AALOX5 | |
| SCHEMBL3546481 | 0.75 | TPMT (0.55) | PPARAKMT2AALOX5PTGS2 | |
| SCHEMBL15656477 | 0.75 | ALOX5 (0.66) | PPARAALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310126-B1 | DERIVATIVES OF PYROCATECHOL-CARBOXYLIC ACID, THEIR PREPARATION AND USE AS ACTIVE INGREDIENTS IN MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-08-18 | — | — | EP | disclosed |
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0310126-A2 | Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-05 | — | — | EP | disclosed |