Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9579690 | 0.90 | LMNA (0.47) | LTB4RLTB4R2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL9510377 | 0.90 | LTB4R (0.55) | LTB4RLTB4R2PPARA | |
| SCHEMBL9508038 | 0.80 | PPARA (0.52) | LTB4RLTB4R2PPARA | |
| SCHEMBL9696967 | 0.79 | LTB4R (0.64) | LTB4RLTB4R2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9016876 | 0.76 | HDAC6 (0.59) | MAPTHDAC6NPC1RAB9ASMPD1 | |
| SCHEMBL11245624 | 0.74 | THRA (0.62) | SMN1; SMN2HSD17B2HDAC6NPC1RAB9A | |
| SCHEMBL29171427 | 0.74 | THRA (0.62) | SMN1; SMN2HSD17B2HDAC6NPC1RAB9A | |
| SCHEMBL2308139 | 0.74 | THRA (0.62) | SMN1; SMN2HSD17B2HDAC6NPC1RAB9A | |
| SCHEMBL29171428 | 0.74 | THRA (0.62) | SMN1; SMN2HSD17B2HDAC6NPC1RAB9A | |
| SCHEMBL29171425 | 0.74 | THRA (0.62) | SMN1; SMN2HSD17B2HDAC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |