SCHEMBL9508152

SCHEMBL9508152

C=C(C)c1ccc(O[Si](C)(C)C)cc1C

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 8/20 0.39
HTT P42858 1/20 0.34
DRD1 P21728 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508147 0.82 HTT (0.34) GSTP1HTT
SCHEMBL16078417 0.79 HTT (0.51) HTTMAPT
SCHEMBL3866565 0.79 HTT (0.44) HTT
SCHEMBL2581744 0.76 KDM4E (0.44) HTTMAPT
SCHEMBL7754386 0.75 MAPT (0.38) MAPT
SCHEMBL11381637 0.74 HAO1 (0.43) HTTMAPT
SCHEMBL13318435 0.73 TP53 (0.46) MAPT
SCHEMBL20027453 0.72 MAPT (0.40) GSTP1HTTDRD1MAPT
SCHEMBL20031602 0.72 MAOA (0.40) MAPT
SCHEMBL8463554 0.71 MAPT (0.32) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0391191-B1 (METH)ACRYLIC POLYMERS GRAFTED WITH POLYCARBONATE CHAINS, THEIR MANUFACTURE AND USE BAYER AG (DE) 1993-09-01 EP disclosed
US-5140066-A Accrylate monomer having trimethylsilyloxy pendant groups; gasoline resistance; impact strength BAYER AKTIENGESELLSCHAFT (DE) 1992-08-18 US disclosed
EP-0292785-B1 VINYL COPOLYMERES CONTAINING GRAFTED POLYCARBONATE CHAINS, THEIR MANUFACTURE AND USE BAYER AG (DE) 1991-06-05 EP disclosed
US-4874816-A IMPROVED RECEPTIVITY OF POLYCARBONATE/POLYSTRYENE BLENDS BY AD DING AN ADDTION CONDENSATION POLYMER HAVING AN UNSATURATED TRI METHYLOXYPHENYL MONOMER OPTICAL DISKS BAYER AKTIENGESELLSCHAFT (DE) 1989-10-17 US disclosed