SCHEMBL9508182

SCHEMBL9508182

O=C(c1ccccc1)c1c(Cl)cc2c(c1Cl)Sc1c(cc(Cl)c(C(=O)c3ccccc3)c1Cl)O2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
ATM Q13315 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAPT P10636 3/20 0.37
HPGD P15428 3/20 0.37
LMNA P02545 2/20 0.37
MEN1 O00255 2/20 0.37
PKM P14618 2/20 0.37
KMT2A Q03164 2/20 0.37
GAA P10253 2/20 0.37
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
HSD17B10 Q99714 1/20 0.37
VCAM1 P19320 1/20 0.36
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
CNR2 P34972 2/20 0.35
CNR1 P21554 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9510067 0.78 AHR (0.35) HPGDMEN1KMT2A
SCHEMBL9507662 0.74 GAA (0.36) ALDH1A1TDP1MAPTHPGDMEN1
SCHEMBL9508936 0.71 AHR (0.35) MEN1KMT2A
SCHEMBL11504324 0.69 ALDH1A1 (0.54) ALDH1A1ATML3MBTL1TDP1MAPT
SCHEMBL27522386 0.69 ALDH1A1 (0.54) ALDH1A1ATML3MBTL1TDP1MAPT
SCHEMBL9511203 0.69 AHR (0.34)
SCHEMBL9511341 0.68 AHR (0.50) ALDH1A1HPGDTSHRMAPK1HSD17B10
SCHEMBL7281793 0.66 ALDH1A1 (0.50) ALDH1A1ATML3MBTL1TDP1MAPT
SCHEMBL7270762 0.66 ALDH1A1 (0.50) ALDH1A1ATML3MBTL1TDP1MAPT
SCHEMBL11210134 0.65 MEN1 (0.50) ALDH1A1ATML3MBTL1TDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0399293-A1 Process for preparing 2-chloro-4-nitro-alkylbenzene BAYER AG (DE) 1990-11-28 EP disclosed