Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | POLA1 | P09884 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508294 | 0.85 | SIGMAR1 (0.48) | SIGMAR1PDK2KDM1ADRD2DRD1 | |
| SCHEMBL9512045 | 0.84 | SIGMAR1 (0.43) | SIGMAR1PDK2KDM1ADRD2DRD1 | |
| SCHEMBL9509089 | 0.82 | PDK2 (0.40) | SIGMAR1PDK2KDM1AOPRM1OPRL1 | |
| SCHEMBL9509760 | 0.79 | KDM1A (0.42) | SIGMAR1KDM1ADRD2 | |
| SCHEMBL9508313 | 0.79 | KDM1A (0.46) | SIGMAR1PDK2KDM1ADRD2DRD1 | |
| SCHEMBL9509084 | 0.72 | SIGMAR1 (0.48) | SIGMAR1PDK2KDM1A | |
| SCHEMBL9509137 | 0.72 | MEN1 (0.42) | SIGMAR1PDK2KDM1A | |
| SCHEMBL6643609 | 0.71 | CYP3A4 (0.52) | SIGMAR1PDK2OPRM1OPRL1POLA1 | |
| SCHEMBL5735496 | 0.71 | KDM1A (0.51) | SIGMAR1KDM1APOLA1 | |
| SCHEMBL12271658 | 0.69 | AR (0.47) | KDM1ADRD2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414686-B1 | DERIVATIVES OF TRIFLUOROMETHYL-1-TETRALINES, PREPARATION AND APPLICATION THEREOF FOR THE SYNTHESIS OF COMPOUNDS HAVING THERAPEUTIC PROPERTIES | LABORATOIRES LUCIEN (FR) | 1993-09-22 | — | — | EP | claimed |
| US-5091429-A | Antidepressant and analgesic with side effects reduction | LABORATOIRES LUCIEN (FR) | 1992-02-25 | — | — | US | disclosed |