Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9509061 | 0.87 | SIGMAR1 (0.46) | KDM1AMEN1KMT2ASIGMAR1TP53 | |
| SCHEMBL9511025 | 0.84 | KIF11 (0.40) | KDM1AMEN1KMT2ASIGMAR1TP53 | |
| SCHEMBL9508294 | 0.84 | SIGMAR1 (0.48) | KDM1AMEN1KMT2ASIGMAR1DRD2 | |
| SCHEMBL9509089 | 0.83 | PDK2 (0.40) | KDM1ASIGMAR1AKR1B1 | |
| SCHEMBL9508313 | 0.83 | KDM1A (0.46) | KDM1ASIGMAR1TP53CYP1A2CYP3A4 | |
| SCHEMBL9509759 | 0.82 | KDM1A (0.40) | KDM1AMEN1KMT2ASIGMAR1TP53 | |
| SCHEMBL9509084 | 0.82 | SIGMAR1 (0.48) | KDM1ASIGMAR1 | |
| SCHEMBL9512045 | 0.80 | SIGMAR1 (0.43) | KDM1AMEN1KMT2ASIGMAR1DRD2 | |
| SCHEMBL9508316 | 0.79 | SIGMAR1 (0.50) | KDM1ASIGMAR1DRD2 | |
| SCHEMBL9509137 | 0.79 | MEN1 (0.42) | KDM1AMEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414686-B1 | DERIVATIVES OF TRIFLUOROMETHYL-1-TETRALINES, PREPARATION AND APPLICATION THEREOF FOR THE SYNTHESIS OF COMPOUNDS HAVING THERAPEUTIC PROPERTIES | LABORATOIRES LUCIEN (FR) | 1993-09-22 | — | — | EP | claimed |
| US-5091429-A | Antidepressant and analgesic with side effects reduction | LABORATOIRES LUCIEN (FR) | 1992-02-25 | — | — | US | disclosed |