Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512045 | 0.85 | SIGMAR1 (0.43) | SIGMAR1MEN1KMT2AKDM1APDK2 | |
| SCHEMBL9508316 | 0.85 | SIGMAR1 (0.50) | SIGMAR1OPRM1OPRL1KDM1APDK2 | |
| SCHEMBL9509760 | 0.84 | KDM1A (0.42) | SIGMAR1AKR1B1MEN1KMT2AKDM1A | |
| SCHEMBL9509137 | 0.82 | MEN1 (0.42) | SIGMAR1MEN1KMT2AKDM1APDK2 | |
| SCHEMBL9509061 | 0.81 | SIGMAR1 (0.46) | SIGMAR1AKR1B1MEN1KMT2AKIF11 | |
| SCHEMBL7321561 | 0.75 | SIGMAR1 (0.51) | SIGMAR1AKR1B1OPRM1OPRL1KIF11 | |
| SCHEMBL9509759 | 0.74 | KDM1A (0.40) | SIGMAR1AKR1B1MEN1KMT2AOPRM1 | |
| SCHEMBL14701153 | 0.73 | SIGMAR1 (0.50) | SIGMAR1AKR1B1OPRM1OPRL1KIF11 | |
| SCHEMBL9511025 | 0.72 | KIF11 (0.40) | SIGMAR1AKR1B1MEN1KMT2AKIF11 | |
| SCHEMBL14220265 | 0.72 | KDM1A (0.46) | SIGMAR1AKR1B1MEN1KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414686-B1 | DERIVATIVES OF TRIFLUOROMETHYL-1-TETRALINES, PREPARATION AND APPLICATION THEREOF FOR THE SYNTHESIS OF COMPOUNDS HAVING THERAPEUTIC PROPERTIES | LABORATOIRES LUCIEN (FR) | 1993-09-22 | — | — | EP | claimed |