Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.35 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508335 | 1.00 | P2RX3 (0.42) | P2RX3TGFBR1TLR2SMPD1FAAH | |
| SCHEMBL9508257 | 0.89 | P2RX3 (0.46) | P2RX3TGFBR1GSTP1GSTM2 | |
| SCHEMBL9508249 | 0.89 | P2RX3 (0.46) | P2RX3TGFBR1GSTP1GSTM2 | |
| SCHEMBL9508940 | 0.78 | OXER1 (0.35) | HPGD | |
| SCHEMBL9508922 | 0.78 | OXER1 (0.35) | HPGD | |
| SCHEMBL23500622 | 0.75 | MEN1 (0.45) | P2RX3TGFBR1GSTP1GSTM2HPGD | |
| SCHEMBL29837066 | 0.75 | MEN1 (0.45) | P2RX3TGFBR1GSTP1GSTM2HPGD | |
| SCHEMBL23500757 | 0.74 | ALDH1A1 (0.45) | P2RX3TGFBR1GSTP1GSTM2HPGD | |
| SCHEMBL9508117 | 0.74 | HDAC1 (0.56) | SMPD1SMN1; SMN2 | |
| SCHEMBL9508113 | 0.74 | HDAC1 (0.56) | SMPD1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |