SCHEMBL9508879

SCHEMBL9508879

Nc1c(Cl)cc2c(c1Cl)Sc1c(cc(Cl)c(N)c1Cl)S2

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
CYP3A4 P08684 1/20 0.39
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
GAA P10253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11707798 0.70 CYP3A4 (0.46) ALDH1A1CYP3A4
SCHEMBL2593530 0.68 CYP3A4 (0.56) ALDH1A1CYP3A4CA1CA2CA9
SCHEMBL9510022 0.65 HSD17B10 (0.43) ALDH1A1CYP3A4
SCHEMBL9510026 0.65 AHR (0.39) ALDH1A1CYP3A4GAA
SCHEMBL7289940 0.64 CYP3A4 (0.59) ALDH1A1CYP3A4CA1CA2CA9
SCHEMBL5074455 0.62 GAA (0.53) ALDH1A1CYP3A4CA1CA2CA9
SCHEMBL1503430 0.62 ALDH1A1 (0.48) ALDH1A1CYP3A4CA1CA2CA9
SCHEMBL11435623 0.61 CYP3A4 (0.31) CYP3A4
SCHEMBL9510057 0.61
SCHEMBL9510120 0.60 ALDH1A1 (0.40) ALDH1A1CYP3A4CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0399293-A1 Process for preparing 2-chloro-4-nitro-alkylbenzene BAYER AG (DE) 1990-11-28 EP disclosed