SCHEMBL9510026

SCHEMBL9510026

Clc1cc2c(cc1Cl)Sc1cc(Cl)c(Cl)cc1S2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 4/20 0.39
MAPK1 P28482 1/20 0.39
FLT1 P17948 1/20 0.37
TSHR P16473 4/20 0.35
HSD17B10 Q99714 3/20 0.35
HPGD P15428 2/20 0.35
TP53 P04637 1/20 0.35
ALDH1A1 P00352 3/20 0.33
CYP3A4 P08684 2/20 0.33
MAPK13 O15264 1/20 0.32
CDK1 P06493 1/20 0.32
PIM1 P11309 1/20 0.32
DYRK1A Q13627 1/20 0.32
PIM3 Q86V86 1/20 0.32
CLK4 Q9HAZ1 1/20 0.32
GAA P10253 1/20 0.32
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
GRIN2D O15399 1/20 0.30
GRIN3B O60391 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11595271 0.85 CD44 (0.35) AHRMAPK1CYP3A4
SCHEMBL9507640 0.78 AHR (0.44) AHR
SCHEMBL9508103 0.78 CD44 (0.46) ALDH1A1CYP3A4GAAKDM4EGRIN2D
SCHEMBL9511324 0.78 ALDH1A1 (0.38) ALDH1A1MEN1MAPTKMT2A
SCHEMBL9507665 0.78 CD44 (0.46) ALDH1A1CYP3A4GAAKDM4EGRIN2D
SCHEMBL9511385 0.76 AHR (0.60) AHRFLT1
SCHEMBL4706870 0.76 NOX1 (0.45) MAPK1CYP3A4GAAMEN1LMNA
SCHEMBL9508960 0.74 AHR (0.45) AHRTP53LMNACYP1A2
SCHEMBL9510022 0.74 HSD17B10 (0.43) MAPK1TSHRHSD17B10HPGDALDH1A1
SCHEMBL4708165 0.73 MAOA (0.43) MAPK1ALDH1A1MEN1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4031147-A CATALYST HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-06-21 US claimed
US-4024198-A Process for the chlorination of toluene HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-05-17 US claimed
US-3989715-A Process for manufacturing chlorothianthrenes HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1976-11-02 US claimed
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0399293-A1 Process for preparing 2-chloro-4-nitro-alkylbenzene BAYER AG (DE) 1990-11-28 EP disclosed
US-4289916-A PHENOXATHIINE AND LEWIS ACID CHLORINATION CATALYST IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1981-09-15 US disclosed
US-4069263-A Process for directed chlorination of alkylbenzenes HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1978-01-17 US disclosed
US-4069264-A CHLORINE, LEWIS ACID CATALYST, THIANTHRENE COMPOUND AS CO-CATALYST HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1978-01-17 US disclosed
US-4031147-A CATALYST HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-06-21 US disclosed
US-4024198-A Process for the chlorination of toluene HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-05-17 US disclosed
US-3989715-A Process for manufacturing chlorothianthrenes HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1976-11-02 US disclosed
US-3989715-A Process for manufacturing chlorothianthrenes HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1976-11-02 US disclosed