SCHEMBL9509099

SCHEMBL9509099

NC(=O)NCc1cnc(-c2ccccc2)o1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 7/20 0.52
HDAC8 Q9BY41 7/20 0.52
HDAC2 Q92769 6/20 0.52
HDAC6 Q9UBN7 5/20 0.52
HDAC4 P56524 5/20 0.52
HDAC3 O15379 4/20 0.52
HDAC7 Q8WUI4 4/20 0.52
HDAC10 Q969S8 4/20 0.52
HDAC11 Q96DB2 4/20 0.52
HDAC9 Q9UKV0 4/20 0.52
HDAC5 Q9UQL6 4/20 0.52
RAB9A P51151 3/20 0.49
ALDH1A1 P00352 3/20 0.49
GAA P10253 3/20 0.49
HPGD P15428 3/20 0.49
KDM4E B2RXH2 2/20 0.49
NPC1 O15118 2/20 0.49
TP53 P04637 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
HSD17B10 Q99714 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9259738 0.80 HDAC1 (0.55) HDAC1HDAC8HDAC2HDAC6HDAC4
Hydrochloric Acid SCHEMBL9264018 0.78 HDAC1 (0.53) HDAC1HDAC8HDAC2HDAC6HDAC4
SCHEMBL9253369 0.75 ALOX5 (0.59) HDAC1HDAC8HDAC2HDAC6HDAC4
SCHEMBL24784588 0.74 HDAC1 (0.55) HDAC1HDAC8HDAC2HDAC6HDAC4
SCHEMBL4652514 0.74 ALOX15 (0.53) HDAC1HDAC8HDAC2HDAC6HDAC4
SCHEMBL12617050 0.73 HDAC1 (0.53) HDAC1HDAC8HDAC2HDAC6HDAC4
Hydrochloric Acid SCHEMBL9512459 0.73 ALOX15 (0.52) HDAC1HDAC8HDAC2HDAC6HDAC4
SCHEMBL9510300 0.71 HDAC1 (0.54) HDAC1HDAC8HDAC2HDAC6HDAC4
SCHEMBL28531830 0.71 RAB9A (0.60) HDAC1HDAC8HDAC2HDAC6HDAC4
SCHEMBL10184678 0.71 HDAC1 (0.56) HDAC1HDAC8HDAC2HDAC6HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0566593-A1 N-HYDROXYUREA DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS PFIZER INC. (US) 1993-10-27 EP disclosed
WO-1992012141-A1 N-HYDROXYUREA DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS PFIZER INC. (US) 1992-07-23 WO disclosed