Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824225 | 0.96 | HDAC8 (0.59) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7814770 | 0.90 | NR4A2 (0.55) | ATMSMN1; SMN2TBXAS1ALDH1A1HPGD | |
| SCHEMBL30089542 | 0.86 | ALDH1A1 (0.53) | ATMSMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL15979732 | 0.86 | ALDH1A1 (0.53) | ATMSMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29573358 | 0.83 | GABRA1 (0.48) | SMN1; SMN2MAPK1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL6686914 | 0.83 | GABRA1 (0.48) | SMN1; SMN2MAPK1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL5253810 | 0.81 | L3MBTL1 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6616967 | 0.81 | HTT (0.50) | ATMMAPK1ALDH1A1MAPTLMNA | |
| SCHEMBL5660953 | 0.81 | ALDH1A1 (0.47) | HDAC1HDAC8SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5253811 | 0.81 | L3MBTL1 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319900-B1 | FURYL, PHENYLENE AND THIENYL LEUKOTRIENE B4 ANALOGUES | G.D. Searle & Co. (US) | 1993-09-29 | — | — | EP | disclosed |
| US-4970229-A | ANTIINFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1990-11-13 | — | — | US | disclosed |
| US-4970234-A | ANTIINFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1990-11-13 | — | — | US | disclosed |
| US-4855324-A | ANTIINFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1989-08-08 | — | — | US | disclosed |
| EP-0319900-A2 | Furyl, phenylene and thienyl leukotriene B4 analogues | G.D. Searle & Co. (US) | 1989-06-14 | — | — | EP | disclosed |