Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28837901 | 0.85 | LMNA (0.47) | LMNATSHRL3MBTL1TDP1ESR1 | |
| SCHEMBL27684342 | 0.79 | TSHR (0.46) | LMNATSHRL3MBTL1TDP1ESR1 | |
| SCHEMBL9837598 | 0.77 | KDM4E (0.45) | TSHRL3MBTL1TDP1MAPK1SMN1; SMN2 | |
| SCHEMBL9308847 | 0.77 | BRD4 (0.50) | LMNATSHRL3MBTL1TDP1MAPK1 | |
| SCHEMBL30049082 | 0.75 | KDM4E (0.50) | LMNATSHRL3MBTL1TDP1MAPK1 | |
| SCHEMBL9684174 | 0.75 | KDM4E (0.50) | LMNATSHRL3MBTL1TDP1MAPK1 | |
| SCHEMBL301816 | 0.74 | TSHR (0.64) | LMNATSHRL3MBTL1TDP1ESR1 | |
| SCHEMBL27520124 | 0.74 | ALDH1A1 (0.52) | LMNATSHRL3MBTL1TDP1ESR1 | |
| SCHEMBL699240 | 0.74 | LMNA (0.51) | LMNATSHRL3MBTL1ESR1MAPK1 | |
| SCHEMBL1465393 | 0.74 | BRD4 (0.47) | LMNATSHRL3MBTL1ESR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557375-A1 | NEW HETEROCYCLIC COMPOUNDS AS ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS, PROCESSES FOR THEIR PREPARATION AND THEIR USE | Astra Aktiebolag (SE) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992008724-A1 | NEW HETEROCYCLIC COMPOUNDS AS ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS, PROCESSES FOR THEIR PREPARATION AND THEIR USE | AKTIEBOLAGET ASTRA (SE) | 1992-05-29 | — | — | WO | disclosed |