Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507937 | 0.88 | CYP19A1 (0.43) | GAAL3MBTL1CYP1A2CYP2C19ADRA1D | |
| SCHEMBL9385171 | 0.85 | SLC6A2 (0.41) | GAAL3MBTL1CYP1A2CYP2C19ADRA1D | |
| SCHEMBL9383431 | 0.81 | HTR6 (0.48) | ADRA1DADRA1AADRA1BKDM4EHPGD | |
| SCHEMBL9671960 | 0.73 | ADRA2A (0.56) | ADRA1DADRA1AADRA1BHPGD | |
| SCHEMBL8123944 | 0.73 | CYP19A1 (0.43) | GAAL3MBTL1CYP19A1KDM4EHPGD | |
| SCHEMBL9507945 | 0.73 | CYP19A1 (0.43) | GAAL3MBTL1CYP1A2CYP2C19CYP19A1 | |
| SCHEMBL9510465 | 0.73 | GAA (0.38) | GAAL3MBTL1CYP1A2CYP2C19CYP19A1 | |
| Hydrochloric Acid SCHEMBL8131705 | 0.69 | HTR6 (0.47) | ADRA1DADRA1AADRA1BCYP19A1KDM4E | |
| SCHEMBL9770197 | 0.68 | TDP1 (0.49) | ADRA1DADRA1AADRA1BCYP19A1HPGD | |
| SCHEMBL3073151 | 0.68 | ITGB2 (0.46) | GAAL3MBTL1CYP1A2CYP2C19CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564520-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-13 | — | — | EP | disclosed |
| WO-1992011011-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| EP-0492021-A1 | Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-01 | — | — | EP | disclosed |