Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8173935 | 0.90 | POLB (0.55) | AGTR1NPC1RAB9APOLBMEN1 | |
| SCHEMBL8173237 | 0.90 | POLB (0.68) | POLBKMT2ACYP3A4CYP2C9 | |
| SCHEMBL9815800 | 0.89 | POLB (0.56) | POLBMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL9425189 | 0.85 | HPGD (0.68) | POLBCYP3A4CYP2C9 | |
| SCHEMBL9425890 | 0.85 | TLR7 (0.64) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL9815864 | 0.82 | ABCB1 (0.60) | POLBCYP3A4CYP2C9 | |
| SCHEMBL9509589 | 0.82 | MEN1 (0.57) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL9815896 | 0.82 | GRM4 (0.55) | — | |
| SCHEMBL8773661 | 0.81 | POLB (0.82) | POLBCYP3A4CYP2C9RECQL | |
| SCHEMBL8773658 | 0.81 | POLB (0.82) | POLBCYP3A4CYP2C9RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361645-B1 | ORGANIC HYDRAZINE DERIVATIVES FOR PHARMACEUTICAL USE | ROHM AND HAAS COMPANY (US) | 1993-09-29 | — | — | EP | disclosed |
| EP-0253468-B1 | SIX-MEMBERED HETEROCYCLIC DERIVATIVES OF N'SUBSTITUTED-N,N'-DIACYLHYDRAZINES | ROHM AND HAAS COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| EP-0361645-A2 | Organic hydrazine derivatives for pharmaceutical use | ROHM AND HAAS COMPANY (US) | 1990-04-04 | — | — | EP | disclosed |