Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635631 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1KMT2AHPGDGAA | |
| SCHEMBL3029269 | 0.78 | ALDH1A1 (0.66) | KDM4EALDH1A1KMT2AHTR2CMAPT | |
| SCHEMBL9512184 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL10639092 | 0.74 | AKT1 (0.60) | KDM4EALDH1A1KMT2AHPGDGAA | |
| SCHEMBL30065886 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1KMT2AHTR2CMAPT | |
| SCHEMBL10638595 | 0.71 | KDM4E (0.39) | KDM4EALDH1A1KMT2AHPGDGAA | |
| SCHEMBL10695261 | 0.70 | BRD4 (0.50) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL11369382 | 0.69 | KDM4E (0.68) | KDM4EALDH1A1KMT2AHTR2CMAPT | |
| SCHEMBL10344387 | 0.69 | BRD4 (0.49) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL11112069 | 0.68 | KDM4E (0.59) | KDM4EALDH1A1HTR2CMAPTAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342664-B1 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | SEARLE & CO (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5093353-A | 2,2-di-substituted benzopyran leukotriene-D4 antagonists | G. D. SEARLE & CO. (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0342664-A2 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | G.D. Searle & Co. (US) | 1989-11-23 | — | — | EP | disclosed |