Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 5/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514419 | 0.88 | MAOB (0.48) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL9513208 | 0.77 | LTB4R (0.43) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL9511642 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL10695261 | 0.76 | BRD4 (0.50) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL10344387 | 0.76 | BRD4 (0.49) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL9514454 | 0.73 | LTB4R (0.43) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL9513652 | 0.73 | LTB4R (0.43) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL9515360 | 0.73 | LTB4R (0.43) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL9515326 | 0.73 | LTB4R (0.43) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL9514470 | 0.73 | PPARD (0.42) | PDK2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342664-B1 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | SEARLE & CO (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5093353-A | 2,2-di-substituted benzopyran leukotriene-D4 antagonists | G. D. SEARLE & CO. (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0342664-A2 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | G.D. Searle & Co. (US) | 1989-11-23 | — | — | EP | disclosed |