Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2-Dichlorobenzene SCHEMBL7965897 | 0.80 | HTR2A (0.44) | — | |
| 1,2-Dichlorobenzene SCHEMBL9643933 | 0.68 | SIGMAR1 (0.54) | TSHR | |
| 1,2-Dichlorobenzene SCHEMBL9641798 | 0.68 | SIGMAR1 (0.46) | — | |
| 1,2-Dichlorobenzene SCHEMBL9643364 | 0.68 | SIGMAR1 (0.53) | — | |
| 1,2-Dichlorobenzene SCHEMBL9643604 | 0.66 | SIGMAR1 (0.43) | TSHR | |
| SCHEMBL11457436 | 0.66 | TSHR (0.54) | TP53MAPTALDH1A1TSHR | |
| SCHEMBL7962593 | 0.64 | OPRK1 (0.62) | TP53ALDH1A1TSHR | |
| SCHEMBL9772465 | 0.64 | OPRK1 (0.62) | TP53ALDH1A1TSHR | |
| SCHEMBL11967793 | 0.63 | RIPK1 (0.62) | TP53MAPTHPGDALDH1A1TSHR | |
| SCHEMBL21393181 | 0.63 | MAPK1 (0.66) | TP53MAPTALDH1A1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0374054-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED, THEIR USE AS MEDICINES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-10-06 | — | — | EP | disclosed |