Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR2C | P28335 | 6/20 | 0.44 |
| ▸ | HTR2B | P41595 | 6/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2-Dichlorobenzene SCHEMBL9511870 | 0.80 | TP53 (0.38) | — | |
| 1,2-Dichlorobenzene SCHEMBL9643933 | 0.79 | SIGMAR1 (0.54) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL9772465 | 0.78 | OPRK1 (0.62) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL7962593 | 0.78 | OPRK1 (0.62) | OPRM1OPRD1OPRK1SIGMAR1 | |
| 1,2-Dichlorobenzene SCHEMBL9643364 | 0.78 | SIGMAR1 (0.53) | OPRM1OPRD1OPRK1SIGMAR1 | |
| 1,2-Dichlorobenzene SCHEMBL9641798 | 0.78 | SIGMAR1 (0.46) | OPRM1OPRD1OPRK1SIGMAR1 | |
| 1,2-Dichlorobenzene SCHEMBL9643604 | 0.76 | SIGMAR1 (0.43) | OPRM1OPRD1OPRK1SIGMAR1 | |
| 1,2-Dichlorobenzene SCHEMBL9510519 | 0.71 | MCOLN2 (0.46) | — | |
| 1,2-Dichlorobenzene SCHEMBL9644127 | 0.68 | SIGMAR1 (0.48) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL8159478 | 0.68 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271395-B1 | E.G.,(.+-.)-N-(2,3-DIHYDRO-2-(1-PYRROLIDINYL)-1H-INDEN-1-Y1) -2 ,4-DINITRO-N-METHYL-BENZENE-ACETAMIDE; STRONG AFFINITY FOR OPTICAL RECEPTORS, CENTRAL ANALGESIC, DIURETIC, ANTIARRYTHMIC, HYPOTENSIVE AND ANTIISCHEMIC ACTIVITY. | HOECHST MARION ROUSSOL (FR) | 2001-08-07 | — | — | US | disclosed |
| EP-0258096-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE INTERMEDIATES OBTAINED | ROUSSEL-UCLAF (FR) | 1992-09-09 | — | — | EP | disclosed |
| EP-0258096-A2 | Indane derivatives, process for their preparation, their use as medicines, pharmaceutical compositions containing them and the intermediates obtained | ROUSSEL-UCLAF (FR) | 1988-03-02 | — | — | EP | disclosed |