Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | TXN | P10599 | 2/20 | 0.50 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514715 | 0.80 | POLB (0.71) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL12368481 | 0.79 | POLB (1.00) | POLBSMN1; SMN2RAB9ANPC1BCHE | |
| SCHEMBL10894311 | 0.77 | SMN1; SMN2 (0.68) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL10644884 | 0.76 | SMN1; SMN2 (0.63) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL10644621 | 0.76 | POLB (0.69) | POLBSMN1; SMN2RAB9ANPC1BCHE | |
| SCHEMBL11108446 | 0.74 | SMN1; SMN2 (0.64) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9519998 | 0.74 | TAAR1 (0.55) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9676986 | 0.73 | POLB (0.60) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9512670 | 0.73 | ALDH1A1 (0.83) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL7745152 | 0.72 | RAB9A (1.00) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0334818-B1 | Pharmacologically active alkylthiobenz imidazole derivatives and process for the preparation thereof | DOMPE FARMACEUTICI SPA (IT) | 1993-12-01 | — | — | EP | disclosed |
| US-4983620-A | ANTIHISTAMINES, ANTIALLERGENS | DOMPE FARMACEUTICI S.P.A. (IT) | 1991-01-08 | — | — | US | disclosed |
| EP-0334818-A1 | Pharmacologically active alkylthiobenz imidazole derivatives and process for the preparation thereof | DOMPE' FARMACEUTICI S.p.A. (IT) | 1989-09-27 | — | — | EP | disclosed |